Fascinating breakdown on the demethylation angle. The distinction between modulating gene expression versus just floodig receptors is something I've noticed with actoprotectors too, and the methyl group analogy as 'duct tape' really clarifies how different this mechanism is from traditional stims. I dunno if the 2006 study ever got follow-up work on tissue selectivity, but the idea that we're optimizing existing pathways instead of burning through them makes way more sense than just hitting dopamine harder.
Fascinating breakdown on the demethylation angle. The distinction between modulating gene expression versus just floodig receptors is something I've noticed with actoprotectors too, and the methyl group analogy as 'duct tape' really clarifies how different this mechanism is from traditional stims. I dunno if the 2006 study ever got follow-up work on tissue selectivity, but the idea that we're optimizing existing pathways instead of burning through them makes way more sense than just hitting dopamine harder.
I'm going to do some follow-up research, in particular if there have been any new actoprotectors developed over the past few decades.